Effects of Neurotrophic Tyrosine Kinase Receptor Type I NTRK1 Polymorphism on Epidural Analgesia with Hydromorphone during Labor

Effects of Neurotrophic Tyrosine Kinase Receptor Type I NTRK1 Polymorphism on Epidural Analgesia with Hydromorphone during Labor

Kangli Lu,¹ Yujiao Huang,¹ Zhicai Chen¹ and Kuncheng Cai¹

¹Department of Anaesthesiology, Central People’s Hospital of Zhanjiang, Zhanjiang City, China

Epidural labor analgesia is a widely employed method of analgesia in current clinical practice. This study aimed to investigate the relationship between NTRK1 gene polymorphism and epidural labor analgesia, offering a novel perspective for labor analgesia related research. Epidural labor analgesia was administered with hydromorphone in 208 eligible pregnant women. Genomic DNA was extracted from EDTA anticoagulant blood samples. The NTRK1 single nucleotide polymorphisms (SNPs) rs1800880 (T > C) and rs6334 (G > A) were genotyped utilizing PCR-RFLP. Parameters such as the 24 h visual analogue score (VAS), modified Bromage score, 48 h patient controlled intravenous analgesia (PCIA) compression counts, dosage of anesthetic, adverse reactions were meticulously recorded. The immune functions were assessed by flow cytometry, and oxidative stress levels were measured by radioimmunoassay. The findings indicated that NTRK1 rs1800880 T > C and rs6334 G > A were similar, 24 h VAS score and anesthetic dosage were decreased. rs1800880 C allele was no significant difference in adverse reactions, but the level of oxidative stress was significantly reduced. The nausea and emesis response of rs6334 mutant AA was significantly reduced. Both rs1800880 TC + CC vs. TT and rs6334 GA + AA vs. GG showed significant effects on 24 h VAS score. Mutations in rs1800880 and rs6334 reduce postoperative pain, adverse reactions, and oxidative stress responses. The NTRK1 SNP may play an important role in labor analgesia and may be an effective predictor of individual pain perception, thereby providing patients with a more personalized approach to labor analgesia

Key words —— epidural analgesia; NTRK1; SNP

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Tohoku J. Exp. Med., 2025 May, 266(3), 257-264.

Correspondence: Kuncheng Cai, Department of Anaesthesiology, Central People’s Hospital of Zhanjiang, No. 236, Yuanzhu Road, Chikan District, Zhanjiang City 524037, Guangdong Province, People’s Republic of China.

e-mail: caikunchengckc@163.com