Association Between Triglyceride Glucose Index and All-Cause Mortality in the Psoriasis Patients

Association Between Triglyceride Glucose Index and All-Cause Mortality in the Psoriasis Patients

Yanqian Su,¹ Huijuan Shi,^1,2 Jue Tang,¹ Siqi Zhao,¹ Xuan Li,¹ Jing Wang¹ and Yanling He¹

¹Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
²Children’s Hospital Capital Institute of Pediatrics, Beijing, China

Triglyceride glucose (TyG) index has been discovered to be significantly associated with a higher risk of mortality. However, the specific association between the TyG index and all-cause mortality in psoriasis patients remains unclear. Data of this study came from the National Health and Nutrition Examination Survey (NHANES). The weighted multivariable Cox regression models and restricted cubic spline (RCS) models were applied to assess the association between the TyG index as continuous variables and tertiles and the risk of mortality. Kaplan-Meier (KM) methods were used to plot survival curves to describe the survival of participants. Additionally, sensitivity and subgroup analyses were conducted to test the robustness of the results. Psoriasis participants who died had substantially higher TyG index than those survived (9.00 ± 0.68 vs. 8.64 ± 0.60, P = 0.008). Multivariable Cox regression showed that TyG index was positively associated to the risk of all-cause mortality (hazard ratios (HR) 1.78, 95% confidence intervals (CI): 1.13-2.81; P = 0.012) after fully adjustment. After converting TyG index from a continuous variable to a categorical variable by tertiles, the unadjusted, partly-adjusted and fully adjusted HR for risk of all-cause mortality were 3.96 (95% CI: 1.47-10.7; P = 0.007), 3.10 (95% CI: 1.20-7.99; P = 0.019) and 3.05 (95% CI: 1.14-8.16; P = 0.027) in participants in tertile 3 of TyG index, compared with tertile 1. The significance of the association persisted across sensitivity and subgroup analysis. The TyG index was positively correlated with the risk of all-cause mortality among psoriasis. These findings suggest that TyG index may be a promising predictor of all-cause mortality for the psoriasis patients during the long-term follow-up.

Key words —— all-cause mortality; psoriasis; triglyceride glucose index; US national survey

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Tohoku J. Exp. Med., 2025 April, 265(4), 201-209.

Correspondence: Yanling He, Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, China.

e-mail: heyanling@ccmu.edu.cn