Etiological Characteristics and Risk Factors of Chronic Obstructive Pulmonary Disease Combined with Infection

Etiological Characteristics and Risk Factors of Chronic Obstructive Pulmonary Disease Combined with Infection

Shaojun Huang¹ and Jinghan Jiang¹

¹Department of General Practice, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College),Wuhu, Anhui, China

The distribution characteristics of pathogenic bacteria and the related health risk of pulmonary infection in patients with chronic obstructive pulmonary disease (COPD) were retrospectively analyzed to develop targeted measures to enhance patient prognosis. A retrospective analysis was conducted on the clinical data of 108 patients with COPD complicated with pulmonary infection and 108 patients without pulmonary infection. Analyze the distribution of pathogens in the lung infection group. Perform univariate analysis on the general data of two groups of patients and use multivariate logistic regression analysis to screen for independent risk factors affecting pulmonary infection in COPD patients. The results of univariate analysis showed that the ratio of patients aged ≥ 60 years, complicated with diabetes, duration of hospitalization ≥ 15 days, type of antimicrobial agents ≥ 2, and transforming growth factor-β (TGF-β) and serum tumor necrosis factor-α (TNF-α) in the pulmonary infection group were significantly greater than those in the group without pulmonary infection. Forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were significantly lower than in the group without pulmonary infection (P < 0.05). Multivariate Logistic regression analysis showed that unrelated health risks for pulmonary infection in COPD patients were age ≥ 60 years, length of hospitalization ≥ 15 days, combination of diabetes mellitus, and use of ≥ 2 types of antibacterial drugs. Age ≥ 60 years old, hospital stay ≥ 15 days, diabetes patients, and antibacterial drugs ≥ 2 are the risk factors of COPD patients with pulmonary infection.

Key words —— chronic obstructive pulmonary disease (COPD); health risk; klebsiella pneumoniae; lung infection; pathogenic bacteria

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Tohoku J. Exp. Med., 2024 December, 264(4), 179-184.

Correspondence: Jinghan Jiang, Department of General Practice, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), No. 2, Zheshan West Road, Jinghu District, Wuhu City, Anhui Province 241100, China.

e-mail: j13956216909@163.com