Shaoyao Gancao Decoction Mitigates Helicobacter Pylori-Induced Chronic Atrophic Gastritis by Suppressing MAOB

Shaoyao Gancao Decoction Mitigates Helicobacter Pylori-Induced Chronic Atrophic Gastritis by Suppressing MAOB

Zhaoyang Li,¹ Xueming He² and Chuming Liu³

¹Department of Chinese Medicine, Harbin Hong Medicine Jingde Clinic, Harbin, Heilongjiang, P.R. China
²Department of Chinese Medicine, Liaoyuan Community Health Service Center, Harbin, Heilongjiang, P.R. China
³Department of Acupuncture and Massage, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, P.R. China

Helicobacter pylori (H. pylori) plays an important role in chronic atrophic gastritis (CAG). Interestingly, Shaoyao Gancao decoction (SGD), a traditional Chinese analgesic prescription, has the efficacy of relaxing spasms and relieving pain. Here, we aimed to identify whether SGD alleviates CAG and the underlying mechanism. A CAG mouse model was developed using H. pylori colonization and a high-salt diet. Histological staining was used to study the histopathological damage changes, and RT-qPCR assays the production of inflammatory responses in the gastric mucosa of mice. H. pylori and a high-salt diet induced gastric mucosal damage and apoptosis of gastric mucosal epithelial cells in mice, eliciting a significant inflammatory response. Treatment with SGD alleviated CAG-induced gastric mucosal damage, reduced apoptosis of gastric mucosal epithelial cells, and inhibited the inflammatory response. Bioinformatics was then used to construct the pharmacological network of SGD to explore its potential targets. SGD inhibited inflammatory response in mice with CAG by suppressing the expression of MAOB. Overexpression of MAOB impaired the therapeutic effect of SGD on inflammation in mice with CAG. Collectively, our findings indicated that SGD has the potential to alleviate CAG via downregulating MAOB.

Key words —— chronic atrophic gastritis; Helicobacter pylori; MAOB; pharmacological network; Shaoyao Gancao decoction

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Tohoku J. Exp. Med., 2024 August, 263(4), 217-226.

Correspondence: Zhaoyang Li, Department of Chinese Medicine, Harbin Hong Medicine Jingde Clinic, No. 1136, Dianchi East Road, Daoli District, Harbin, Heilongjiang 150000, P.R. China.

e-mail: L_zhaoyang11@163.com