Impact of Inflammation-Related Genes on COVID-19: Prospective Study at Turkish Cohort

Impact of Inflammation-Related Genes on COVID-19: Prospective Study at Turkish Cohort

Ahmet Cevdet Ceylan,^1,2 Branur avdarl,² Glay Gle Ceylan,^1,2 Vehap Topu,² S. Betl Arslan Satlm,² erife Gkbulut Bekta,³ Aye K. Kalem,^4,5 Bircan Kayaaslan,^4,5 Fatma Eser,^4,5 Emra Asfurolu Kalkan,⁶ Osman nan,⁶ mran Hasanolu,^4,5 Selcen Yksel,⁷ hsan Ate,⁸ Seval zde,^3,9 Rahmet Gner^4,5 and C. Nur Semerci Gndz^1,2

¹Department of Medical Genetics, Faculty of Medicine, Ankara Yldrm Beyazt University, Ankara, Turkey
²Department of Medical Genetics, Ankara City Hospital, Ankara, Turkey
³Department of Anesthesiology and Reanimation-Critical Care, Ankara City Hospital, Ankara, Turkey
⁴Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ankara Yldrm Beyazt University, Ankara, Turkey
⁵Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara, Turkey
⁶Department of Internal Medicine, Ankara City Hospital, Ankara, Turkey
⁷Department of Biostatistics, Ankara Yldrm Beyazt University, Ankara, Turkey
⁸Department of Internal Medicine, Ankara City Hospital, Health Science University, Ankara, Turkey
⁹Department of Anesthesiology and Reanimation-Critical Care, Faculty of Medicine, Ankara Yldrm Beyazt University, Ankara, Turkey

The pandemic coronavirus disease 2019 (COVID-19) has caused a high mortality rate and poses a significant threat to the population. The disease may progress with mild symptoms or may cause the need for intensive care, depending on many factors. In this study, it was aimed to determine if there is a tendency due to genetic factors in COVID-19 patients. Ninety-four of 188 patients with mild clinical and 94 with severe clinical symptoms were included in the study. The targeted panel including coagulopathy ( Since polymorphic variants were not evaluated in the literature, the findings of our study could not be compared with the literature. However, as variants that may be effective in the severity of infections may differ according to ethnicity. This study has the feature of being a guide for subsequent studies to be carried out especially in Turkish population. Clinical course of the COVID-19 is likely to depend on a variety of risk factors, including age, sex, clinical status, immunology and genetic factors.

Key words —— COVID-19; IRF7; new variants; polymorphic variants; risks of severe disease

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Tohoku J. Exp. Med., 2023 November, 261(3), 179-185.

Correspondence: C. Nur Semerci Gndz, M.D., Department of Medical Genetics, Ankara City Hospital, University District 1604. Street No.9, Bilkent, ankaya, Ankara 06800, Turkey.

e-mail: nsemerci1@yahoo.com