Tohoku J. Exp. Med., 2023 July, 260(3)

Review

Impact of Octacalcium Phosphate/Gelatin (OCP/Gel) Composite on Bone Repair in Refractory Bone Defects

Yu Mori,¹ Ryo Hamai,² Toshimi Aizawa¹ and Osamu Suzuki²

¹Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
²Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, Japan

In clinical settings, bone grafting is frequently used to treat bone defects. Therefore, the development of bone graft substitutes with superior bone formation ability is expected, instead of autogenous bone grafting. Octacalcium phosphate (OCP) has been developed as a bone graft substitute, and preclinical studies using OCP have reported superior bone formation ability compared with β-tricalcium phosphate. Furthermore, OCP has been used in composite forms with natural polymers such as collagen and gelatin to improve the usability of OCP, and OCP/collagen composite forms have been clinically applied in the dental field because of their excellent usability and osteogenic potential. This review describes the development and preclinical results of OCP and OCP/gelatin (OCP/Gel) composites and prospects for future applications in orthopedics. The development of bone graft substitutes that achieve a high degree of biodegradability and strength will be needed for the clinical application of OCP composites in orthopedics in the future.

Key words —— biodegradation; bone graft substitute; gelatin; octacalcium phosphate; osteogenesis

© 2023 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2023 July, 260(3), 245-252.

Correspondence: Osamu Suzuki, Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

e-mail: suzuki-o@tohoku.ac.jp