Tohoku J. Exp. Med., 2023 February, 259(4)

Videofluoroscopic Dysphagia Scale as an Additional Indicator of Gastrostomy in Patients with Amyotrophic Lateral Sclerosis with Dysphagia

Tomomi Shijo,¹ Ryoukichi Ikeda,² Naoki Suzuki,¹ Jun Ohta,² Jun Suzuki,² Ai Hirano-Kawamoto,² Kengo Kato,² Kensuke Ikeda,¹ Rumiko Izumi,¹ Shio Mitsuzawa,³ Hitoshi Warita,¹ Masaaki Kato,³ Masashi Aoki¹ and Yukio Katori²

¹Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
²Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
³Department of Neurology, Shodo-kai Southern Tohoku General Hospital, Iwanuma, Miyagi, Japan

Pseudobulbar palsy and bulbar palsy cause dysphagia in patients with amyotrophic lateral sclerosis (ALS). Dysphagia in patients with ALS not only increases the risk of aspiration and pneumonia but also leads to malnutrition and weight loss, which are poor prognostic factors. Gastrostomy is the preferred route of feeding and nutritional support in patients with dysphagia. However, there are no established standards to determine the ideal timing of gastrostomy for patients with ALS. Therefore, we used the videofluoroscopic dysphagia scale (VDS), which objectively quantifies swallowing function, in videofluoroscopic swallowing study (VFSS) to investigate whether this scale at diagnosis can be a useful predictor for the timing of gastrostomy. We retrospectively evaluated 22 patients with ALS who were diagnosed at our hospital. We assessed the VDS scores in all patients within 3 months of diagnosis. A decline in the ALS functional rating scale revised (ALSFRS-R) scores was used as an indicator of disease progression. As a result, we found that the VDS score of the pharyngeal phase and the total VDS score were significantly correlated with the ΔALSFRS-R scores. These scores were also associated with the existing indicators for the timing of gastrostomy, i.e., decreased body weight and percent-predicted forced vital capacity. We demonstrated the noninferiority of the VDS scores relative to the existing indicators. In addition, the VDS score of the pharyngeal phase was significantly correlated with the time from diagnosis to gastrostomy. The VDS score could estimate the timing of gastrostomy in patients with ALS with dysphagia at diagnosis.

Keywords —— amyotrophic lateral sclerosis; dysphagia; gastrostomy; videofluoroscopic dysphagia scale; videofluoroscopic swallowing study

© 2023 Tohoku University Medical Press

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Tohoku J. Exp. Med 2023, 259, 293-300.

Correspondence: Masashi Aoki, M.D., Ph.D., Department of Neurology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.

e-mail: aokim@med.tohoku.ac.jp