Analysis of Diagnostic Value of Electrogastrography for Parkinson’s Disease and its Predictive Value for the Disease Progression
Zhining Li,1 You Lv,1 Xingyi Cao,1 Liangqun Rong,1 Xiue Wei,1 Haiyan Liu,1 Zhendong Wang2 and Aiping Gong1
1Department of Neurology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
2Digestive Department, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
The study aimed to evaluate the diagnostic and prognostic value of indexes detected by electrogastrography in Parkinson’s disease patients. One hundred twenty early Parkinson’s disease patients and 120 healthy controls were recruited, and underwent electrogastrography to detect dominant frequency (DF), instability coefficient of DF (ICDF), low frequency range (LFR), high frequency range (HFR), and normal frequency range (NFR). The receiver operating characteristic (ROC) curve was drawn for the diagnostic value analysis. The motor function was scored with the Unified Parkinson’s Disease Rating Scale (UPDRS). Sniffin’ Sticks test was used for the olfactory evaluation, and the TDI score consisting of odor threshold (T), odor discrimination (D) and odor identification (I) tests was calculated. The preprandial ICDF of Parkinson’s disease patients was significantly higher than that of the control group, and decreased slowly during the late postprandial phase. The levels of LFR%, HFR% and NFR% in Parkinson’s disease patients were higher than the control group during both the preprandial and late postprandial phase, and the changes of each index before and after meals were not obvious. Preprandial ICDF value and TDI score had the ability to distinguish Parkinson’s disease patients with the AUC of 0.874 and 0.859 respectively. The ICDF detected by electrogastrography has high clinical value in the early diagnosis of Parkinson’s disease, and the combination of ICDF and TDI can improve the diagnostic sensitivity and specificity of a single indicator. High ICDF levels during the preprandial phase are related to the poor prognosis of Parkinson’s disease patients after treatment.
Keywords —— electrogastrography; gastrointestinal dysfunction; instability coefficient of dominant frequency; Parkinson’s disease
© 2022 Tohoku University Medical Press
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Tohoku J. Exp. Med 2022, 258, 213-218.
Correspondence: Aiping Gong, Department of Neurology, The Second Affiliated Hospital of Xuzhou Medical University, No. 32 Meijian Road, Xuzhou, Jiangsu 221000, China.
e-mail: gong_aiping@163.com