Tohoku J. Exp. Med., 2022 November, 258(3)

Sjögren’s Syndrome Presenting with Temporary Hemiplegia Mimicking Transient Ischemic Attack

Yukiko Kamogawa,¹ Kanae Akita,¹ Hiroko Sato,¹ Tsuyoshi Shirai,¹ Tomonori Ishii,² Hideo Harigae³ and Hiroshi Fujii¹

¹Department of Rheumatology, Tohoku University Hospital, Sendai, Miyagi, Japan
²Department of Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Miyagi, Japan
³Department of Hematology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

Sjögren’s syndrome manifests with a wide variety of neurologic symptoms. This case report presents a 53-year-old woman with Sjögren’s syndrome associated with temporal hemiplegia, which was suspected to be a transient ischemic attack. After induction of immunosuppressive therapies [high-dose prednisolone (1 mg/kg/day) and intravenous cyclophosphamide (total 5 g)], the hemiplegia did not reappear and the blood flow abnormalities remarkably improved as depicted on electroencephalography and single photon emission computed tomography. This case suggests that temporal hemiplegia presenting with transient ischemia-like attack symptoms may be a neurologic manifestation of Sjögren’s syndrome and responsive to immunosuppressive therapy.

Keywords —— extraglandular manifestation; immunosuppressive therapy; neurological symptom; Sjögren’s syndrome; transient ischemic attack

© 2022 Tohoku University Medical Press

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Tohoku J. Exp. Med 2022, 258, 207-211.

Correspondence: Hiroshi Fujii M.D., Ph.D., Department of Rheumatology, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.

e-mail: hfujii@med.tohoku.ac.jp