Tohoku J. Exp. Med., 2022 September, 258(1)

Detection of Secondary Corneal Lactoferrin Amyloidosis Based on Histologic Biopsies Combined with Mass Spectrometry: A Case Report

Hong Tang,¹ Wenhui Liu,² Rui Wu,³ Feifei Zhao⁴ and Min Xie⁵

¹Department of Pathology, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, Jiangsu, China
²Department of Ophthalmology, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, Jiangsu, China
³Department of Pathology, the Third Affiliated Hospital of Peking University, Beijing, China
⁴Department of Infectious Disease, Wuxi Children’s Hospital, Wuxi, Jiangsu, China
⁵Department of Radiology, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, Jiangsu, China

Amyloidosis is characterized by systemic or local deposition of amyloid fibrils outside organs and tissues. Amyloidosis is rarely seen on cornea. A 30-year-old woman patient had had trichiasis in both eyes for 8 years. Trichiasis was observed, which touched the cornea. Slit lamp microscopy showed white gelatinous droplet-like eminences and trichiasis in the lower cornea of the right eye. Optical coherence tomography showed that the lesion involved most of the cornea. Hematoxylin and eosin staining showed that most of the stroma stained red, with scattered inflammatory cells. High expression of lactoferrin was detected by mass spectrometry, and the case was diagnosed as secondary corneal lactoferrin amyloidosis in the right eye.

Keywords —— amyloidosis; case report; cornea; lactoferrin; mass spectrometry analysis

© 2022 Tohoku University Medical Press

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Tohoku J. Exp. Med 2022, 258, 43-48.

Correspondence: Min Xie, 68 Zhongshan Road, Department of Radiology, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, Jiangsu 214002, China.

e-mail: xiesheng68@aliyun.com