Tohoku J. Exp. Med., 2021 November, 255(4)

Analyzing Correlation of Clinical Severity of COVID-19 with Other Biochemical Parameters: A Retrospective Study from Pakistan

Syed Sib tul Hassan Shah,1 Iqra Naeem1 and Braira Wahid2

1Department of Life Science, School of Science, University of Management and Technology (UMT), Lahore, Pakistan
2Laboratory of Antimicrobial Systems Pharmacology, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia

The third wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing damage all over the world, especially in Pakistan and India. Although vaccines are available and preventive measures are being taken, but SARS-CoV-2 is unstoppable. Currently, there are around 841,636 positive cases in Pakistan and 18,429 deaths, whereas, in India, both are high. From April 8th to 12th, 2021, nasopharyngeal swabs of 190 patients were submitted to PRL (PACP) lab for the SARS-CoV-2 testing, and blood samples were collected at the Mayo Hospital lab for ferritin, D-dimers, lactate dehydrogenase (LDH), and C-reactive protein (CRP) testing. This study observed that coronavirus disease 2019 (COVID-19) was more likely in individuals aged 51-60 than 61-70. In addition, our study found that COVID-19 patients exhibited a statistically significant increase in levels of ferritin, D-dimers, LDH, and CRP. In addition, this study revealed that SARS-CoV-2 relapsed. Furthermore, we concluded that these biochemical parameters are useful indicators for severity of COVID-19.

Keywords —— biochemical markers; clinical severity; COVID-19; Lahore; SARS-CoV-2y


Tohoku J. Exp. Med 2021, 255, 315-323.

Correspondence: Syed Sib tul Hassan Shah, Department of Life Sciences, School of Science, University of Management and Technology, C-II, Johar Town, Lahore 54770, Pakistan.