Behçet’s Disease with Extremely High Levels of Urinary β2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment

Behçet’s Disease with Extremely High Levels of Urinary β2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment

Ryohei Ogino,¹ Karin Shimada,¹ Daiki Narai,¹ Masanori Goto,¹ Katsuhiro Sato,¹ Yoshihisa Katsuta,¹ Akimasa Shiigi,¹ Juri Ueda,¹ Chika Oyama,¹ Yuko Fujikawa,¹ Isabelle Miyazawa,¹ Takahiro Ohara,¹ Kazuhiro Sumitomo,¹ Shigeru Sato,¹ Nobuo Koinuma,¹ Atsuhiro Kanno¹ and Katsutoshi Furukawa¹

¹Division of Community Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan

Behçet’s disease is an inflammatory disease which manifests itself as various symptoms, such as uveitis, oral and genital aphthae, erythema nodosa, gastro-intestinal ulcerations and encephalopathy. Among the manifestations, renal dysfunction is reported in some percentage of the patients with this disorder. We experienced a middle-aged male with Behçet’s disease who showed an extremely high level of urinary β2-microglulin, which is one of the markers of renal dysfunction, despite normal serum creatinine levels. The patient was on non-steroidal anti-inflammatory drug (NSAID) therapy for 7 weeks, and this could have affected his renal dysfunction. The present report suggests that renal injury should not be underestimated in patients with Behçet’s disease, especially in patients using NSAIDs.

Keywords —— Behçet’s disease; β2-microglobulin; creatinine; non-steroidal anti-inflammatory drug; renal dysfunction

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Tohoku J. Exp. Med., 2021, 254, 283-286

Correspondence: Katsutoshi Furukawa, M.D., Ph.D., Division of Community Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi 983-8536, Japan.

e-mail:kfurukawa-kf@umin.ac.jp