Tohoku J. Exp. Med., 2021 March, 253(3)

Cerebral Aneurysm Rupture during Pregnancy Resulting in Subdural Hematoma without Subarachnoid Hemorrhage

Yoshimitsu Wada,1 Hirotada Suzuki,1 Teppei Matsubara,2 Hironori Takahashi,3 Hiroyuki Fujiwara3 and Shigeki Matsubara3

1Department of Obstetrics and Gynecology, Sano Kosei General Hospital, Sano, Tochigi, Japan
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA
3Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Tochigi, Japan

Subarachnoid hemorrhage is typically present in cerebral aneurysm rupture, whereas acute subdural hematoma without subarachnoid hemorrhage is rare. We herein report a case of cerebral aneurysm rupture during pregnancy resulting in acute subdural hematoma without subarachnoid hemorrhage. A 37-year-old gravida 4 para 3 pregnant woman was admitted for threatened preterm labor at 294/7 weeks of gestation. At 296/7 weeks of gestation (day 14), she developed mild left eye pain, which disappeared within one day. At 316/7 weeks of gestation (day 0), she developed the sudden onset of severe headache and nausea. A neurological examination revealed no abnormal findings, and analgesics ameliorated her headache. At 321/7 weeks of gestation (day 2), after consultations with neurosurgeons, magnetic resonance imaging showed acute subdural hematoma without subarachnoid hemorrhage. Further examinations revealed a cerebral aneurysm. Emergent clipping surgery was performed with the fetus in utero in consideration of the immaturity of the fetus and stable maternal/fetal general conditions. At 356/7 weeks of gestation (day 28), her headache of unknown cause recurred. Considering the maturity of the fetus, the patient underwent cesarean section with good maternal and neonatal outcomes. The absence of subarachnoid hemorrhage does not eliminate cerebral aneurysm rupture.

Key words —— cerebral aneurysm rupture; clipping surgery; pregnancy; solitary acute subdural hematoma; subarachnoid hemorrhage

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Tohoku J. Exp. Med 2021 253, 199-202.

Correspondence: Hirotada Suzuki M.D., Ph.D., Department of Obstetrics and Gynecology, Sano Kosei General Hospital, 1728 Horigome-cho, Sano, Tochigi 327-8511, Japan.

e-mail: killip@jichi.ac.jp