Polygenic risk score and its application in Alzheimer's disease

Masataka Kikuchi

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo

The purpose of the polygenic risk score (PRS) is to determine the degree of genetic susceptibility to Alzheimer's disease.　This article outlines the process for calculating PRS and introduces its application in AD, including a new and improved score.　This article also discusses potential concerns for PRS's clinical use.

Address correspondence to Dr. Masataka Kikuchi, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo(6-2-3 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan)