Lipid nutrition for promoting neurogenesis from the perspective of dementia intervention

Noriko Osumi

Tohoku University Graduate School of MedicineTohoku University Graduate School of Medicine

The brain, which conducts higher functions, is developed gradually from the earliest stages of embryonic development.　The brain continues to develop both morphologically and functionally after birth.　It was previously believed that the number of neurons peaked at 3 years of age and subsequently progressively declined.　Nonetheless, it is now shown that stem cells persist in certain regions of the brain and neurons are generated throughout life (neurogenesis).　Since neurogenesis is associated with memory and emotion, it has been suggested that alterations in its condition may also be associated with psychiatric problems.　Neurogenesis is also known to be altered by environmental factors including exercise, sleep, and diet.　The brain is rich in lipid, and therefore, lipid nutrition is a key for promoting neurogenesis.　In this work, we will examine dementia therapies from the standpoint of neurogenesis.

Address correspondence to Dr. Noriko Osumi, Tohoku University Graduate School of Medicine(2-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan)