Microglial homeostasis in tauopathy mouse models

Naruhiko Sahara

Department of Functional Brain Imaging, Institute of Quantum Medical Science, National Institutes for Quantum Science and Technology

The role of the added layer of signals encoded in the glial circuit has always been an enigma.　Recent findings show that glial cells in the cerebellum react to excitatory transmitter glutamate released from synapses of neurons and glial cells release additional glutamate in return.　Glutamate released from glial cells efficiently activated metabotropic glutamate receptors on Purkinje neurons, which is known to be essential for cerebellar motor learning.　It is possible that glial cells could have a pivotal role on memory formation.　A therapeutic strategy designed to target glial cells could possibly realize memory enhancement for treating dementia.

Address correspondence to Dr. Naruhiko Sahara, Department of Functional Brain Imaging, Institute of Quantum Medical Science, National Institutes for Quantum Science and Technology（4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan）