Pathological role of Aβ, Tau and ApoE:Insights from the mouse models

Takashi Saito

Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences

A number of evidences from the investigations of Alzheimer’s disease （AD） showed that Aβ and tau play a central role of AD pathogenesis.　ApoE4 is also identified as the strongest risk factor of AD pathogenesis, compared with ApoE2 and ApoE3.　Although pathological relationships among Aβ, tau and ApoE were studied well until now, detailed molecular/cellular mechanisms of ApoE underlying AD pathogenesis are still unclear.　In this review, I would summarize recent findings of the role of ApoE on AD pathogenesis in the mouse models, and discuss future perspectives of ApoE as the druggable target for AD.

Address correspondence to Dr. Takashi Saito, Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences（1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan）