Molecular mechanism why Gaucher’s disease gene desruption cause Parkinson’s disease through Toll-like receptor;its application to neurodegenerative disease

Norio Ishida, Kunpei Ito, Eiji Inoue, Tsubasa Takahara, Haruhisa Kawasaki, Takahiro Suzuki

Institute for Chronobiology, Foundation for Advancement of International Science （FAIS）

GBA（glucocerebrosidase）mutations are the most common genetic risk factor of Parkinson’s disease.　But, the molecular mechanism is totally unknown.　We have found out the upregulation of 26-29-p gene and toll-like receptor gene in GBA mutant flies.　Thus, we hypothesized that the local inflammation cause α-Synuclein aggregation from cellular immunity through toll-like receptor.　This paper indicated the possibility of new treatment for neurodegenerative diseases such as Gaucher’s disease as well as Parkinson’s disease.

Address correspondence to Dr. Norio Ishida, Institute for Chronobiology, Foundation for Advancement of International Science （FAIS）（24-16-3 Kasuga, Tsukuba, Ibaraki 305-0821, Japan）