Dementia Japan 34:28-34, 2020

The relationship between Parkinson’s disease and gut micirobiota

Masaaki Hirayama

Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine

Many bacteria have established a symbiotic relationship with the host over the course of their long evolution. Intestinal microbiota are important for human life.
Microbial-based therapies for various central nervous system （CNS） disorders, including Parkinson’s disease （PD）, may be developed in the future.
In this review, we report a recent study of intestinal microbiota that may be involved in PD symptoms and progression. In particular, since the use of proton pump inhibitor increases the risk of dementia, we will focus on small intestinal bacterial overgrowth.

Address correspondence to Dr. Masaaki Hirayama, Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine （1-1-20 Daikominami, Higashi-ku, Nagoya-shi, Aichi 461-8673, Japan