Dementia Japan 34:8-12, 2020

Glial cells protecting neurons from neuroinflammation in the brain

Yasuhsia Tamura, Yosky Kataoka

Laboratory for Cellular Function Imaging, RIKEN Center for Biosystems Dynamics Research, Multi-Modal Microstructure Analysis Unit, RIKEN-JEOL Collaboration Center

Neuroinflammation is related to pathogenesis of neurodegenerative diseases, including Alzheimer’s disease, and coordinated by activity of neuron-glia networks. Microglia and astrocytes are associated with pro-inflammatory responses in adult brain, whereas cells that participate in anti-inflammatory responses remain unclear. Experimental studies showed that NG2 glia might regulate suppression of microglial activation and maintain brain environment via the control of inflammatory responses.

Address correspondence to Dr. Yosky Kataoka, Laboratory for Cellular Function Imaging, RIKEN Center for Biosystems Dynamics Research, Multi-Modal Microstructure Analysis Unit, RIKEN-JEOL Collaboration Center （6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan）