Neurological adverse effects following use of gastrointestinal drugs

Noriko Sudo

Center for Health Check-up and Preventive Medicine, Kanto Central Hospital

Center for Health Check-up and Preventive Medicine Commonly used gastrointestinal drugs including Histamin-2 receptor antagonist (H2RA), proton pump inhibitor (PPI), antiemetics and promotility drugs are extensively prescribed in the world. While these drugs are generally considered safe, some of these drugs can occasionally lead to neurologic adverse effects, especially in elderly. A rage of neurologic adverse effects that have been reported following use of these gastrointestinal drugs are headache, dizziness, extrapyramidal syndromes, mood disorder, delirium, dementia and so on. We review association between each drugs and neurological adverse effect, for instance between PPI and dementia.

Address correspondence to Dr. Noriko Sudo, Center for Health Check-up and Preventive Medicine, Kanto Central Hospital (6-25-1 Kamiyoga, Setagaya-ku, Tokyo 158-8531, Japan)