Mild cognitive impairment in Parkinson’s disease:pathophysiology and symptomatology

Mild cognitive impairment in Parkinson's disease:pathophysiology and symptomatology

Kouichi Ohta

Department of Neurology, Tachikawa Hospital

The Movement Disorder Society commissioned a task force in 2011 to critically evaluate the literature on mild cognitive impairment in Parkinson's disease (PD-MCI) and concluded that:(1) PD-MCI is common, (2) it has significant heterogeneity in the number and types of cognitive domain impairments, (3) it appears to place patients at risk of progressing to dementia. Keio PD data base study, a large cross-sectional study in Japan, has suggested that PD-MCI may be 47% of Japanese PD population, and that the most frequent subtypes may be PD-MCI single-domain (executive function) (25%) and PD-MCI multiple domain (executive function and memory) (24%). Cambridgeshire Parkinson's Incidence from GP to Neurologist (CamPaIGN) study, a cohort study for 10 years in UK, has demonstated that baseline clinical (age, motor impairment, and posterior-cortical cognitive deficits) and genetic (MAPT genotype) variables are predictive of development to demantia in PD patients.

Address correspondence to Dr. Kouichi Ohta, Department of Neurology, Tachikawa Hospital(4-2-22 Nishikicho, Tachikawa, Tokyo 190-8531, Japan)