Dementia Japan 30:95-102, 2016

Amyloid hypothesis and tau hypothesis

Fuyuki Kametani, Masato Hasegawa

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science

The long-standing “amyloid hypothesis” that Alzheimer's disease is cause by the production and aggregation of amyloid-beta faces serious challenges by data recently obtained from neuroimaging studies and amyloid-beta-focused clinical trials.  In this review, we inspect a problem of amyloid hypothesis and propose a new hypothesis based on accumulating evidences and new findings.

Address correspondence to Dr. Fuyuki Kametani, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science(2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan)