Current situation of tau imaging

Yukitsuka Kudo¹⁾, Nobuyuki Okamura¹⁾²⁾, Shozo Furumoto³⁾, Ryuichi Harada¹⁾,Aiko Ishiki⁴⁾, Katutoshi Furukawa⁴⁾, Kazuhiko Yanai²⁾, Hiroyuki Arai⁴⁾

¹⁾Division of Neuro-Imaging, Institute of Development, Aging and Cancer, Tohoku University
²⁾Department of Pharmacology, Tohoku University School of Medicine
³⁾Diviosion of Radiopharmaceutical Chemistry, Cycrotoron and Radioisotope Center, Tohoku University
⁴⁾Department of Geriatrics & Gerontology, Division of Brain Science, Institute of Development, Aging and Cancer, Tohoku University

Several promising tau probes have been developed by Tohoku University (［¹⁸F］THK series), National Institute of Radiological Sciences (［¹¹C］ PBB3), and Eli Lilly (［¹⁸F］T807and ［¹⁸F］T808). The kuzuhara·Ihara theory, partial volume effect, and tau pathology in AD were discussed in this paper. It will be certain that tau imaging plays an important role in a study for pre-stage of Preclinical AD.

Address correspondence to Dr. Yukitsuka Kudo, Division of Neuro-Imaging, Institute of Development, Aging and Cancer, Tohoku University(4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan)