RNA binding proteins in neurodegenerative disease ─Prospect for a therapy in disease modeling using iPS cells─

RNA binding proteins in neurodegenerative disease
─Prospect for a therapy in disease modeling using iPS cells─

Naohiro Egawa, Haruhisa Inoue

Center for iPS Cell Research and Application (CiRA), Kyoto University

Recent analyses have revealed that RNA processing machinery play crucial roles in the pathogenesis of neurodegeneration. Mutations in the genes encoding for RNA binding proteins have been identified to cause neurodegenerative disease.On the contrary, induced pluripotent stem cell (iPSC) research shows neurodegenerative disease modeling with aberrant RNA splicing.We reviewed the function of RNA binding proteins and the potential therapeutic target for RNA processing in neurodegenerative disease using iPSCs.

Address correspondence to Dr. Haruhisa Inoue, Center for iPS Cell Research and Application (CiRA), Kyoto University (53 Kawahara-Cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan)