DLB and PDD

Hideo Mori

Department of Neurology, Juntendo University School of Medicine,
Department of Neurology, Juntendo Koshigaya Hospital

The relationship between dementia with Lewy bodies (DLB) and Parkinson disease with dementia (PDD) has been a matter of controversy.　The neuropathology of most patients with DLB or PDD is DLBD or transitional type of Lewy body disease (LBD) and there is no pathological hallmark which distinguishes these disease conditions.　The cognitive profiles of DLB and PDD are similar and there is overlap of clinical features of DLB and PDD.　There is no distinctive difference between DLB and PDD except for the timing of onset of dementia.　DLB and PDD are considered different clinical phenotype of a single disease, LBD.　LBD encompasses several clinical phenotype including Parkinson disease, PDD and DLB.　Alternatively, it can be said DLB is a form of Parkinson disease if the term of Parkinson disease is valued.

Address correspondence to Dr. Hideo Mori, Department of Neurology, Juntendo University School of Medicine, Department of Neurology, Juntendo Koshigaya Hospital (560, Fukuroyama, Koshigaya, Saitama 343-0032, Japan)