Tohoku J. Exp. Med., 2022 May, 257(1)

Transient Type 3 Renal Tubular Acidosis during Cyclic Vomiting Syndrome

Naonori Kumagai,¹ Tomomi Kondoh,¹ Yuji Matsumoto¹ and Yohei Ikezumi¹

¹Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

Type 3 renal tubular acidosis is a pathological condition characterized by the simultaneous occurrence of distal renal tubular acidosis, which causes urinary acidification disorders, and proximal renal tubular acidosis, which causes impaired reabsorption of bicarbonate ions. Type 3 renal tubular acidosis is considered rare. A 5-year-old boy was admitted to our hospital because of frequent vomiting, poor vitality, and fever. He was diagnosed with cyclic vomiting syndrome. Type 3 renal tubular acidosis was also diagnosed because of severe mixed metabolic acidosis with impaired urinary acidification, a low tubular phosphorus reabsorption rate with hypophosphatemia, low-molecular-weight proteinuria, pan-aminoaciduria, and glucosuria. Fluid infusion was performed. On the second day of hospitalization, the vomiting disappeared and the patient was able to eat and drink. He was discharged on the eighth day of hospitalization. The laboratory test abnormalities associated with the renal tubular acidosis gradually improved, and testing at discharge on the eighth day of admission showed no metabolic acidosis, hypophosphatemia, low-molecular-weight proteinuria, or glucosuria. These findings suggested that the type 3 renal tubular acidosis was transient. Severe metabolic acidosis was observed in this patient because of both normal anion gap metabolic acidosis due to type 3 renal tubular acidosis and anion gap metabolic acidosis due to cyclic vomiting syndrome. Although type 3 tubular acidosis is rare, the resultant metabolic acidosis worsens when combined with a disease that causes metabolic acidosis. Type 3 tubular acidosis should be ruled out when severe metabolic acidosis is present.

Keywords —— anion gap metabolic acidosis; cyclic vomiting syndrome; delta gap; normal anion gap metabolic acidosis; type 3 renal tubular acidosis

© 2022 Tohoku University Medical Press

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Tohoku J. Exp. Med 2022, 257, 73-76.

Correspondence: Naonori Kumagai, Department of Pediatrics, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.

e-mail: nkumagai@fujita-hu.ac.jp