Tohoku J. Exp. Med., 2019 December, 249(4)

Malignancies in Patients with IgG4-Related Diseases in Head and Neck Regions

RYOUKICHI IKEDA,¹ KAZUYA KURAKAMI,² NOBUO OHTA,¹ TAKAHIRO SUZUKI,¹ YUTARO SAITO,¹ YUSUKE KUSANO,¹ MUNEHARU YAMAZAKI,¹ YUTAKA TATEDA,¹ SHIORI KITAYA,¹ SEIJI KAKEHATA,² HIDETOSHI TAKAHASHI³ and KENNICHI SATOH⁴

¹Division of Otolaryngology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan
²Department of Otolaryngology-Head and Neck Surgery, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan
³Division of Ophthalmology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan
⁴Division of Gastroenterology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan

Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized disease, characterized by high serum IgG4 concentrations and IgG4-producing plasma cell expansion with fibrotic or sclerotic changes in affected organs. Recent work has focused on the relationship between IgG4-RD and malignancies, but there is no report of malignancies associated with IgG4-RD in head and neck regions. The aim of this study was to analyze the clinicopathological characteristics of malignancies in patients with IgG4-RD in head and neck regions. We retrospectively analyzed 26 patients with IgG4-RD (12 men and 14 women aged 60.6 ± 11.6 years). The mean follow-up period was 26.6 months (from 12 to 96 months). These patients were divided into single-lesion group (n = 12) with IgG4-RD only in head and neck regions and multiple-lesion group (n = 14) with IgG4-RD in other regions. There was no significant difference in serum IgG4 concentrations between the single-lesion group (459.4 ± 336.4 mg/dL) and the multiple-lesion group (908.0 ± 739.2 mg/dL) (P = 0.07), whereas the IgG4/IgG ratio was significantly lower in the single-lesion group (22.8 ± 11.0%; n = 11) compared with the multiple-lesion group (31.7 ± 15.0%; n = 11, P = 0.02). Among the 26 patients, two patients (7.7%), both in the multiple-lesion group, developed life-threatening malignancies (salivary duct carcinoma in the submandibular gland and lymphoma in the orbital tissue). All physicians need to keep in mind the possible coexistence of malignancies in patients with IgG4-RD with high IgG4/IgG ratio and multiple lesions at the time of diagnosis.

Keywords —— head and neck regions; IgG4-related diseases; lymphoma; malignancy; salivary duct carcinoma

© 2019 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2019, 249, 285-290

Correspondence: Nobuo Ohta, Division of Otolaryngology, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi 983-8536, Japan.

e-mail: noohta@hosp.tohoku-mpu.ac.jp