Tohoku J. Exp. Med., 2019 June, 248(2)

Asthma Exacerbation Coincident with Saddle Pulmonary Embolism and Paradoxical Embolism

TAKEHIRO HASHIMOTO,¹ MASARU ANDO,¹ TAKAMASA KAN,¹ NOBUHIRO FUJISHIMA,¹ MARI YAMASUE,¹ KOSAKU KOMIYA,¹ KENJI UMEKI,¹ SHIN-ICHI NUREKI¹ and JUN-ICHI KADOTA¹

¹Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Yufu, Oita, Japan

Saddle pulmonary embolism (PE) and paradoxical embolism (PDE) are life-threatening disorders carrying a risk of sudden death, and their prompt diagnosis is extremely important. Saddle PE is a radiologic definition and refers to a thrombus that straddles the bifurcation of the pulmonary artery trunk, carrying a risk of sudden hemodynamic collapse. PDE is defined as a systemic arterial embolus due to the passage of a venous thrombus though a right-to-left shunt, such as patent foramen ovale (PFO). We herein present the rare case of asthma exacerbation coincident with saddle PE and PDE. A 69-year-old woman with asthma was suffering from dyspnea, pulse attenuation of the left radial artery and left upper limb pain. An arterial blood gas analysis revealed hypoxemia, and a pulmonary function test demonstrated an obstructive pattern. Enhanced computed tomography (CT) revealed saddle PE, right popliteal venous thrombosis, and left brachial artery occlusion. After the treatment with edoxaban, an anticoagulant, and aspirin, the PE was significantly alleviated, and the brachial artery occlusion was recanalized. Subsequently, the right-to-left shunt through PFO was confirmed, and PDE was suspected of inducting her brachial artery embolism. In the present case, the pulse attenuation of the radial artery and upper limb pain prompted us to consider peripheral vascular disease or coagulation disorders. Physicians should keep in mind that patients with asthma are at considerable risk of PE, and it is important to be aware of possible PFO in patients presenting with the coexistence of PE and systemic arterial embolism.

keywords —— anticoagulant therapy; asthma exacerbation; brachial artery embolism; paradoxical embolism; saddle pulmonary embolism

© 2019 Tohoku University Medical Press

===============================

Tohoku J. Exp. Med., 2019, 248, 137-141

Correspondence: Masaru Ando, M.D., Ph.D., Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan.

e-mail: mando@oita-u.ac.jp