Tohoku J. Exp. Med., 2017 May, 242(1)

Prognostic Factors for In-Hospital and Long-Term Survival in Patients with Acute ST-Segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention

LIN-LIN HOU,^1,2 CHAO GAO,² JUN FENG,² ZHEN-FEI CHEN,² JING ZHANG,² YONG-JIN JIANG,² XUE-XIANG LI³ and BANG-NING WANG¹

¹Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P.R. China
²Department of Cardiology, The Second People Hospital of Hefei, Hefei, Anhui, P.R. China
³Department of Emergency Medicine, The Second Hospital of Anhui Medical University, Hefei, Anhui, P.R. China

Acute ST segment elevation myocardial infarction (STEMI) is one of the causes of death and disability in patients with cardiovascular diseases. This study aimed to investigate the prognostic factors of in-hospital and long-term survival in patients with acute STEMI undergoing percutaneous coronary intervention (PCI). Patients with STEMI undergoing PCI were divided into the death group (n = 54) and the survival group (n = 306) based on the outcomes during hospitalization. The routine blood and biochemistry tests, Killip classes and global registry of acute coronary events (GRACE) risk score were detected. The 1-, 2- and 3-year survival rates after PCI was observed through a 3-year follow-up. The survival factors, survival rates and multivariate analyses were conducted using Logistic regression analysis, Kaplan-Meier survival analysis and Cox proportional hazards regression. The incidence of cardiogenic shock and anterior wall MI (AWMI), the serum levels of γ-glutamyl endopeptidase (γ-GGT) and creatine kinase isoenzyme MB (CK-MB), Killip classes and GRACE risk score were higher in the death group, compared with the survival group. AWMI, cardiogenic shock, high serum levels of γ-GGT and CK-MB, Killip class III-IV and high GRACE risk scores were associated with in-hospital mortality. AWMI, cardiogenic shock, Killip class III-IV and high GRACE risk scores were correlated with a poor long-term survival. Our findings have demonstrated that AWMI, cardiogenic shock, high serum levels of γ-GGT and CK-MB, Killip class III-IV, and high GRACE risk scores are risk factors for in-hospital and long-term prognosis of acute STEMI patients.

keywords —— Keywords: acute ST-segment elevation myocardial infarction; in-hospital survival; long-term survival; percutaneous coronary intervention; prognostic factor

© 2017 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2017, 242, 27-35

Correspondence: Bang-Ning Wang, Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui Province 230022, P.R. China.

e-mail: wangbangning@medmail.com.cn