Papillary Thyroid Carcinoma: A Malignant Tumor with Increased Antioxidant Defense Capacity

Papillary Thyroid Carcinoma: A Malignant Tumor with Increased Antioxidant Defense Capacity

BRANISLAV R. ROVCANIN,¹ KRISTINA R. GOPCEVIC,² DUSAN LJ. KEKIC,² VLADAN R. ZIVALJEVIC,¹ ALEKSANDAR DJ. DIKLIC¹ and IVAN R. PAUNOVIC¹

¹Center for Endocrine Surgery, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
²Institute for Chemistry in Medicine, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Papillary thyroid carcinoma (PTC) is the commonest thyroid malignancy worldwide for which the radiation exposure is the most influential risk factor. The levels of oxidative stress in PTC are not well characterized on the tissue level. The objective of this study was to evaluate total oxidant status (TOS) and total antioxidant status (TAS) in PTC and benign goiter (BG) tissues and to examine their association with clinicopathological characteristics. Tumor and normal thyroid tissue samples were collected from 59 PTC patients, and goiter tissues were collected from 50 BG patients. TOS and TAS were quantified in the tissue homogenates by spectrophotometric assays. TOS values in tumor tissues did not differ significantly from normal and goiter tissues; however, PTC tissues have significantly higher TAS values than normal and goiter tissues. TOS values correlated with retrosternal growth in BG patients. The significant correlations were found between TOS and TAS values and thyroid function parameters. In 17 PTC patients with multiple tumor foci (multicentric phenotype), TAS values were significantly lower, compared to 42 patients with unicentric PTC. TAS and TOS are the most useful predictors of thyroid capsular invasion by PTC. The age, sex, body mass index, smoking, familial history of thyroid disease and nodule size did not influence TOS and TAS in PTC or BG patients. In conclusion, we show the profiles of TOS and TAS in PTC and BG tissues. Importantly, PTC tissues possess increased antioxidant capacity. The redox status influences the parameters of the thyroid function and tumor's biological behavior.

keywords —— benign goiter; oxidative stress index; papillary thyroid carcinoma; total antioxidant status; total oxidant status

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Tohoku J. Exp. Med., 2016, 240, 101-111

Correspondence: Branislav Rovcanin, M.D., MSc., Center for Endocrine Surgery, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Koste Todorovica 8, Belgrade 11000, Serbia.

e-mail: rovcaninb@yahoo.com