Tohoku J. Exp. Med., 2011, 224(2)

Deep-Vein Thrombosis Is Associated with Large Uterine Fibroids

MITSURU SHIOTA,¹ YASUSHI KOTANI,¹ MASAHIKO UMEMOTO,¹ TAKAKO TOBIUME,¹ MITSUHIRO TSURITANI,¹ MASAO SHIMAOKA¹ and HIROSHI HOSHIAI¹

¹Department of Obstetrics and Gynecology, Kinki University Faculty of Medicine, Osaka, Japan

Pulmonary thromboembolism (PE) may occur upon a patient's first postoperative attempt of ambulation. PE is a serious complication, often leading to shock or sudden death. Reported rates of PE following gynecologic surgery are between 0.3% and 0.8%, while the incidence of postoperative deep-vein thrombosis (DVT), the major cause of PE, is between 17% and 20%. Therefore, effective preventive measures, such as preoperative assesment for asymptomatic DVT, should be considered. It is well known that DVT and/or PE are associated with large uterine fibroids, the common, benign tumor of myometrium. Here, to establish the statistical relationship between DVT risk and uterine fibroid size/weight, we assessed the preoperative DVT rate with respect to three possible risk factors: age, obesity level, and uterine size/weight. A total of 361 patients with uterine fibroids undergoing hysterectomy between July, 2003 and December, 2009 were enrolled. All patients were evaluated for preoperative DVT; the results were stratified for statistical comparison by patient age, BMI, and uterine weight. There was no statistical difference in the DVT rate for patients stratified by age (below age 45 years or older) or BMI (below 25 or higher). By contrast, the rate of DVT was significantly higher for patients with uterine weights of 1,000 gm or more (11.5% [7/61]) compared with weights below 1,000 gm (3.0% [9/300]). None of the patients studied developed PE. In conclusion, the incidence of DVT is significantly higher in cases where uterine weight is 1,000 gm or more (ie, adult head size on pelvic examination).

keywords —— D-dimer; deep vein thrombosis; pulmonary thromboembolism; uterine fibroid; weight of uterus

© 2011 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2011, 224, 87-89

Correspondence: Mitsuru Shiota, Department of Obstetrics and Gynecology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-sayama, Osaka, 589-8511, Japan.

e-mail: shiota@med.kindai.ac.jp