Tohoku J. Exp. Med., 2010, 222(4)

Nucleoside Analogue Therapy Following One-Year Course of Hepatitis B Immunoglobulin in Preventing Hepatitis B Virus Reactivation after Living Donor Liver Transplantation

NAOKI KAWAGISHI,¹ IKUO TAKEDA,² SHIGEHITO MIYAGI,² KAZUSHIGE SATOH,² YORIHIRO AKAMATSU,² SATOSHI SEKIGUCHI² and SUSUMU SATOMI²

¹Division of Organ Transplantation, Tohoku University Hospital, Sendai, Miyagi, Japan
²Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan

The combination therapy with hepatitis B immunoglobulin (HBIG) and nucleoside analogue is well tolerated for the hepatitis B recipients after liver transplantation, but its cost is an important problem in these days. Here we report the efficacy of nucleoside analogue therapy following one-year course of HBIG plus nucleoside analogue after living donor liver transplantation (LDLT). Out of 103 LDLTs, we selected 14 recipients who received the post-transplant therapy against reactivation of hepatitis B virus for more than 30 months. Those were eight patients with chronic hepatitis B, three with fulminant hepatitis, and three whose donors were positive for antibody to HB core antigen (HBc). During two days after the operation, HBIG (40,000 units) was administered, and the serum level of antibody to HB surface antigen (HBs) was maintained at around 150 IU/L for one year by monthly administration of HBIG. After one year, HBIG was withdrawn. A nucleoside analogue was administered daily from just after LDLT, and it was continued up to the present. Among the 14 patients, two recipients had recurrence of hepatitis B. Three patients, including one patient with recurrence of hepatitis B, died due to hepatocellular carcinoma or its associated cirrhosis; namely, their deaths are unrelated to hepatitis B-related diseases. The remaining 11 patients are leading normal lives. In conclusion, nucleoside analogue therapy after one-year course of HBIG plus nucleoside analogue is feasible and cost-effective in preventing HBV reactivation. But the patients are still at risk of breakthrough and some patients may need continued prophylaxis with HBIG.

keywords —— lamivudine; entecavir; HBIG; living donor liver transplantation; HBV

© 2010 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2010, 222, 275-279

Correspondence : Naoki Kawagishi, Division of Organ Transplantation, Tohoku University Hospital, 1-1 Seiryou-machi, Aoba-ku, Sendai, 980-8574, Japan.

e-mail: kawan@med.tohoku.ac.jp