Tohoku J. Exp. Med., 2008, 215(2)

Differences in Left Ventricular Hypertrophy and Dysfunction Between Patients with Cerebral Hemorrhage and Those with Cerebral Infarction

HISASHI MASUGATA,¹ SHOICHI SENDA,¹ FUMINORI GODA,¹ AYUMU YAMAGAMI,¹ HIROYUKI OKUYAMA,¹ TAKEAKI KOHNO,¹ NAOHISA HOSOMI,³ MASANOBU IMAI,² KAZUSHI YUKIIRI³ and MASAKAZU KOHNO³

¹Department of Integrated Medicine, Kagawa University, Kagawa, Japan
²Kagawa General Rehabilitation Center, Kagawa, Japan
³Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University, Kagawa, Japan

Left ventricular (LV) hypertrophy and dysfunction due to hypertension have been established as risk markers for stroke in hypertensive patients. The purpose of this study was to examine the differences in LV hypertrophy and dysfunction between patients with cerebral hemorrhage and those with cerebral infarction. The study enrolled 23 hypertensive patients with cerebral infarction, 25 hypertensive patients with cerebral hemorrhage, and 24 normotensive controls (controls). Standard echocardiography was performed; LV mass index was measured to evaluate LV hypertrophy, and conventional diastolic transmitral flow velocities were measured to assess LV diastolic function, which was also evaluated by measuring mitral annular velocities using tissue Doppler echocardiography. The Tei index, which reflects both the diastolic and systolic function of LV, was also calculated. The LV mass index and Tei index were significantly higher in cerebral hemorrhage (116 ± 38 g/m² and 0.57 ± 0.13) than those in controls (92 ± 20 g/m² and 0.46 ± 0.10) (p < 0.05). In contrast, the LV mass index and Tei index in cerebral infarction (100 ± 27 g/m² and 0.46 ± 0.12) were not different from those in controls. Thus, the Tei index was significantly worse in the patients with cerebral hemorrhage than in those with cerebral infarction (p < 0.05). On the other hand, the parameters, which reflect diastolic function, showed no significant differences between cerebral hemorrhage and cerebral infarction. These results indicate that LV hypertrophy and dysfunction due to hypertension are more apparent in patients with cerebral hemorrhage than in those with cerebral infarction.

keywords —— hypertension; cerebral hemorrhage; cerebral infarction; echocardiography; left ventricular hypertrophy.

© 2008 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2008, 215, 159-165

Correspondence: Hisashi Masugata, M.D., Department of Integrated Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

e-mail: masugata@med.kagawa-u.ac.jp