Tohoku J. Exp. Med., 2008, 215(1)

Benefit of Combined Cardiac Rehabilitation on Exercise Capacity and Cardiovascular Parameters in Patients with Type 2 Diabetes

HANA SVACINOVÁ,¹ MARIE NOVÁKOVÁ,² ZDENEK PLACHETA,¹ MASAHIRO KOHZUKI,³ MAKOTO NAGASAKA,³ NAOYOSHI MINAMI,³ PETR DOBŠÁK¹ and JARMILA SIEGELOVÁ¹

¹Department of Functional Diagnostics and Rehabilitation, St. Anna's Faculty Hospital and Masaryk University, Brno, Czech Republic
²Department of Physiology, Masaryk University, Brno, Czech Republic
³Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Japan

Favorable effects of exercise training on cardiovascular prognosis have been reported repeatedly in patients with diabetes mellitus type 2 (DM2). However, little is known about the cardiovascular rehabilitation effects in diabetic patients with coronary artery disease (CAD). This study has evaluated the benefits of combined aerobic-resistance training in two groups of patients - diabetics and non-diabetics - after percutaneous coronary intervention (PCI). Changes in exercise capacity parameters, resting cardiovascular and anthropometrical parameters were evaluated in 77 patients who completed 12-weeks of combined aerobic-resistance training: 32 patients with DM2 (DM) and 45 patients without DM2 (NDM). Significant improvements in exercise capacity (total peak workload [W_peak], peak workload per kg of body weight [W_peak/kg], total peak oxygen uptake [VO_2peak], peak oxygen uptake per kg of body weight [VO_2peak/kg]) were found in both DM and NDM (p < 0.01 and p < 0.001, respectively). The decrease in resting heart rate (HR_rest), resting systolic (SBP_rest) resting diastolic (DBP_rest) blood pressures, body weight (BW) and BMI in the DM group was not statistically significant. However, there was a statistically significant decrease in SBP_rest, BW and BMI in the NDM group. In conclusion, this study demonstrated similar beneficial effects of combined cardiovascular training on exercise capacity in patients with or without type 2 diabetes mellitus. Our results suggest that the combined cardiac training is well tolerated and useful in secondary prevention in patients with DM2 and CAD.

keywords —— type 2 diabetes mellitus; cardiac rehabilitation; aerobic-resistance training; exercise capacity.

© 2008 Tohoku University Medical Press

===============================

Tohoku J. Exp. Med., 2008, 215, 103-111

Correspondence: Hana Svacinová, M.D., Ph.D., Department of Functional Diagnostics and Rehabilitation, St. Anna's Faculty Hospital, Pekarska 53, 656 91 Brno, Czech Republic.

e-mail: hana.svacinova@fnusa.cz