Tohoku J. Exp. Med., 2007, 213(4)

Soft Tissue Gas Gangrene: A Severe Complication of Emphysematous Cholecystitis

MICHAEL SAFIOLEAS,¹ MICHAEL STAMATAKOS,¹ MELETIOS KANAKIS,² CONSTANTINA SARGEDI,¹ CONSTANTINOS SAFIOLEAS,¹ ANASTASIOS SMIRNIS¹ and GEORGE VAIOPOULOS²

¹Second Department of Propedeutic Surgery, Medical School, University of Athens, Laiko General Hospital, Athens, Greece
²First Department of Internal Medicine, Medical School, Univercity of Athens, Laiko General Hospital, Athens, Greece

Soft tissue gas gangrene with myonecrosis is a severe complication of traumatic and non-traumatic conditions with a potentially lethal outcome. Emphysematous cholecystitis is a complication of acute cholecystitis, which is characterized by air accumulation in the gallbladder wall and is reported in the literature as a rare causative factor of soft tissue gas gangrene. Here we report 4 patients who developed soft tissue gas gangrene as a complication of emphysematous cholecystitis. Two patients were female octogenarians (one with a history of diabetes mellitus), and underwent percutaneous trans-gallbladder drainage and fascia incisions of the affected soft tissue with prompt administration of antibiotics. Finally, both of them died. The other two patients were male (32 years old diabetic and 47 years old with a history of chronic alcoholism). They underwent open cholecystectomy. Fascia incisions of the gangrenous areas and antibiotic therapy administration were also performed. Both of them were discharged from the hospital and are currently in excellent clinical status. We also present the ultrasonographic and/or radiologic images of these four patients. Soft tissue gas gangrene may complicate emphysematous cholecystitis, and clinicians should be aware of the coexistence of these two clinical conditions, since immediate management is needed in order to prevent fatal outcome.

keywords —— gas gangrene; Myonecrosis; Cholecystitis; Emphysematous; complication

© 2007 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2007, 213, 323-328

Correspondence: Prof. Michael Safioleas, M.D., Ph.D., 7 Kyprou Ave. Filothei, 15237 Athens, Greece.

e-mail: stamatakosmih@yahoo.gr