Tohoku J. Exp. Med., 2007, 213(1)

Coronary Artery Bypass Grafting Ameliorates the Decreased Plasma Adiponectin Level in Atherosclerotic Patients

ZEYNEP EYILETEN,¹ MAHMUT ILKER YILMAZ,² KAAN KAYA,³ A. RUCHAN AKAR,¹ DOGAN KAHRAMAN,¹ SEZIN BINGOL,⁴ ADNAN UYSALEL¹ and UMIT OZYURDA¹

¹Department of Cardiovascular Surgery, Ankara University School of Medicine, Ankara, Turkey
²Department of Nephrology, Gulhane School of Medicine, Ankara, Turkey
³Department of Cardiovascular Surgery, Umut Hospital, Ankara, Turkey
⁴Department of Biochemistry, Numune Hospital, Ankara, Turkey

Adiponectin functions as an anti-inflammatory and anti-atherogenic factor, and the decreased plasma adiponectin is a risk factor for coronary disease. The aim of this study was to determine the changes in plasma levels of adiponectin, a potential parameter for atherosclerosis, in patients underwent surgical revascularization. We included forty patients with atherosclerosis (age, 58 ± 9 years; body mass index [BMI] 26.93 ± 2.3 kg/m²) undergoing coronary artery bypass grafting (CABG). Control group consisted of 40 healthy volunteers, matched for age, gender and BMI (age, 56 ± 6 years; BMI, 26.78 ± 2.3 kg/m²). We measured various parameters, including high sensitive C-reactive protein (hsCRP), homeostasis model assessment-insulin resistance (HOMA-IR) indexes, and adiponectin. The baseline profile of the patients before CABG showed higher levels of serum hsCRP (13.15 ± 2.40 mg/l vs 3.97 ± 1.07 mg/l) and HOMA-IR (1.86 ± 0.30 vs 1.26 ± 0.33) and lower plasma adiponectin levels (7.02 ± 2.01 μg/ml vs 25.46 ± 3.9 μg/ml), compared to controls (p < 0.001 for each parameter). Plasma adiponectin level was increased one month after CABG from the baseline level to 8.67 ± 2.05 μg/ml (p < 0.001), although the level was still lower than the control value. Thus, postoperative adiponectin level might be helpful for evaluating the progression of atherosclerosis. Moreover, CABG significantly decreased hsCRP to 7.25 ± 1.89 mg/l and HOMA-IR to 1.59 ± 0.33, although these levels were higher than the controls. These results suggest that CABG decreases the cardiac risk factors in atherosclerotic patients.

keywords —— adiponectin; coronary artery bypass grafting; insulin sensitivity; oxidative stress

© 2007 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2007, 213, 71-77

Correspondence: Zeynep Eyileten, M.D., Department of Cardiovascular Surgery, Heart Center, Ankara University School of Medicine, Dikimevi, Ankara, Turkey.

e-mail: zeynepb1965@yahoo.com