Tohoku J. Exp. Med., 2007, 212(3)

High Serum Homocysteine Levels Correlate with a Decrease in the Blood Flow Velocity of the Ophthalmic Artery in Highway Toll Collectors

RAMAZAN MEMISOGULLARI,¹ HARUN YÜKSEL,² ABDURRAHMAN COSKUN,¹ HATICE KURT YÜKSEL,¹ ÖMER YAZGAN³ and CAHIT BILGIN⁴

¹Department of Biochemistry, Medical Faculty, Düzce University, Düzce, Turkey
²Department of Ophthalmology, Medical Faculty, Düzce University, Düzce, Turkey
³Department of Radiology, Medical Faculty, Düzce University, Düzce, Turkey
⁴Department of Chest Diseases, Düzce University, Medical Faculty, Düzce, Turkey

Highway workers, such as policemen, automotive service companies, and toll collectors, are placed at risk of the accelerated atherosclerotic process, since recent studies have suggested that exposure to exhaust particles and ambient air pollution increases carotid intima-media thickness and reduces ocular blood flow velocity. Therefore, we assessed the relationship between serum homocysteine, a potential parameter for atherosclerosis, and the ocular blood flow velocity and the resistivity index in highway toll collectors. The peak systolic and end diastolic flow velocities and the resistivity index were measured in 22 toll collectors and 24 control subjects by color Doppler ultrasonography. The resistivity index, which is an indirect measure of the atherosclerotic process, was calculated: resistivity index = (peak systolic velocity - end diastolic velocity)/peak systolic velocity. Serum homocysteine levels were determined by fluorometric high-performance liquid chromatography. In the highway toll collectors, the serum homocysteine level (14.4 ± 4.8 μmol/l; p < 0.005) and the resistivity index of the ophthalmic artery (0.741 ± 0.015; p < 0.05) were higher and the ophthalmic blood flow velocity (33.0 ± 3.0 cm/s; p < 0.001) was lower than those in the controls (10.6 ± 3.1 μmol/l; 0.728 ± 0.023; 36.8 ± 2.2 cm/s; respectively). There were significant correlations between the serum homocysteine level and ophthalmic artery resistivity index in both highway toll collectors (p < 0.001) and controls (p < 0.005). Exposure to exhaust particles might increase the serum homocysteine level, which in turn could lead to the decreased ocular blood flow and the increased resistivity index.

keywords —— homocysteine; ocular blood flow; highway toll collectors; color Doppler ultrasonography

© 2007 Tohoku University Medical Press

===============================

Tohoku J. Exp. Med., 2007, 212, 247-252

Correspondence: Ramazan Memisogullari, M.D., Department of Biochemistry, Düzce University, Medical School, 81620 Düzce, Turkey.

e-mail: rmemisogullari@hotmail.com, rmemisogullari@gmail.com