Historical Trends in Human Serum Levels of Perfluorooctanoate and Perfluorooctane Sulfonate in Shenyang, China

Historical Trends in Human Serum Levels of Perfluorooctanoate and Perfluorooctane Sulfonate in Shenyang, China

YIHE JIN,^1,2 NORIMITSU SAITO,³ KOUJI H. HARADA,⁴ KAYOKO INOUE⁴ and AKIO KOIZUMI⁴

¹Department of Environmental Science and Technology, Dalian University of Technology, Dalian, P.R. China
²Division of Hygienic Toxicology, School of Public Health, China Medical University, Shenyang, P.R. China
³Research Institute for Environmental Sciences and Public Health of Iwate Prefecture, Morioka, Japan
⁴Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan

Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are widespread contaminants in the environment, as well as in wildlife and in humans. The PFOS and PFOA concentrations were determined in historical human serum samples collected in Shenyang, China, in 1987 (n = 15), 1990 (n = 33), 1999 (n = 68) and 2002 (n = 119). The serum donors were students, faculty members and university workers. Since the serum PFOA and PFOS levels did not follow a normal or log-normal distribution, a nonparametric method was applied to analyze the historical trends. For the total male and female subjects, the median level of serum PFOA increased significantly from 0.08 μg/l in 1987 to 4.3 μg/l in 2002 (p < 0.05), while the median level of serum PFOS also increased significantly from 0.03 μg/l in 1987 to 22.4 μg/l in 2002 (p < 0.05). Both the serum PFOA and PFOS levels continued to increase from 1999 to 2002, with remarkable increases observed in females: 6.3-fold increase for PFOA and 13-fold increase for PFOS. In 2002, serum PFOA and PFOS concentrations of female subjects have increased to 4.9 μg/l and 22.4 μg/l in median, respectively, which are comparable to those in U.S.A. and Japan. For male subjects, serum PFOA and PFOS concentrations (1.6 μg/l and 8.3 μg/l in median, respectively) are comparable to those in Italy. The data from this study indicate that females are likely to experience higher exposure to these chemicals.

keywords —— perfluorooctane sulfonate; perfluorooctanoate; serum; long-term trend; China

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Tohoku J. Exp. Med., 2007, 212, 63-70

Correspondence: Akio Koizumi M.D., Ph.D., Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, 606-8501 Kyoto, Japan.

e-mail: koizumi@pbh.med.kyoto-u.ac.jp