Tohoku J. Exp. Med., 2007, 211(2)

Neuroendocrine System Response Modulates Oxidative Cellular Damage in Burn Patients

XIAO-QI XIE,¹ YOTARO SHINOZAWA,¹ JUNICHI SASAKI,¹ KIYOTSUGU TAKUMA,¹ SATOSHI AKAISHI,¹ SATOSHI YAMANOUCHI,¹ TOMOYUKI ENDO,¹ RYOSUKE NOMURA,¹ MICHIO KOBAYASHI,¹ DAISUKE KUDO¹ and NOBUKO HOJO¹

¹Division of Emergency Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Oxygen-derived free radicals play important roles in pathophysiological processes in critically ill patients, but the data characterizing relationships between radicals and neuroendocrine system response are sparse. To search the cue to reduce the oxidative cellular damage from the point of view of neuroendocrine system response, we studied the indicators of neuroendocrine and inflammatory responses excreted in urine in 14 burn patients (42.3 ± 31.4 years old, and 32.3 ± 27.6% burn of total body surface area [%TBSA]) during the first seven days post burn. The daily mean amounts of urinary excretion of 8-hydroxy-2'-deoxy-guanosine (8-OHdG), a marker of oxidative cellular damage, were above the upper limit of the standard value during the studied period. The total amount of urinary excretion of 8-OHdG in the first day post burn correlated with burn severity indices: %TBSA (r = 0.63, p = 0.021) and burn index (r = 0.70, p = 0.008). The daily urinary excretion of 8-OHdG correlated with the daily urinary excretion of norepinephrine and nitrite plus nitrate (NOx) during the studied period except day 2 post burn, and correlated with the daily urinary excretion of 17-hydroxycorticosteriod (17-OHCS) in days 2, 3, and 7 post burn. These data suggest that oxidative cellular damage correlates with burn severity and neuroendocrine system response modulates inflammation and oxidative cellular damage. Modulation of neuroendocrine system response and inflammation in the treatment in the early phase of burn may be useful to reduce the oxidative cellular damage and to prevent multiple organ failures in patients with extensive burn.

keywords —— free radical; 8-OHdG; norepinephrine; 17-OHCS; nitrogen oxide

© 2007 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2007, 211, 161-169

Correspondence: Yotaro Shinozawa, Division of Emergency Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

e-mail: sinozawa@gonryo.med.tohoku.ac.jp