Multiple Clinical Presentations of Anal Ultra Slow Waves and High Anal Pressure: Megacolon, Hemorrhoids and Constipation

Multiple Clinical Presentations of Anal Ultra Slow Waves and High Anal Pressure: Megacolon, Hemorrhoids and Constipation

HIROAKI YOSHINO,^1* HIROYUKI KAYABA,^2* TATSUZO HEBIGUCHI,¹ MAYAKO MORII,¹ TAKU HEBIGUCHI,¹ WATARU ITO,² JUNICHI CHIHARA² and TETSUO KATO¹

¹Department of Pediatric Surgery, Akita University School of Medicine, Akita, Japan
²Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, Japan

The physiopathology of idiopathic chronic constipation is complex and yet to be investigated. In the manometric studies of the patients with severe chronic constipation, we noticed that some patients with megacolon show very slow periodical (< 2/min) pressure change in the anal canal, namely ultra slow waves (USWs). USWs are considered to represent the hyperactivity of the internal anal sphincter; however, USW-related clinical presentations have yet to be investigated. We retrospectively re-evaluated the patient records and manometric studies of 85 cases, 51 subjects without defecatory problems and 34 patients with constipation, to elucidate USW-related clinical presentations. USWs were seen in 10 patients, including eight patients with chronic constipation and two subjects without defecatory problems. Out of the eight patients with constipation, one had no organic change in the anorectum, three had hemorrhoids and four exhibited megacolon. Manometric and pathological studies proved that none of the four patients with magacolon was suffering from Hirschsprung's disease. Among the 51 subjects without defecatory problems, only two had USWs. Anal pressure in the USW-positive group (106.0 ± 37.0 cmH₂O) was significantly higher than that in the group without defecatory problems (56.0 ± 27.0 cmH₂O) or constipated patients without USWs (55.0 ± 26.0 cmH₂O). Megacolon and high anal pressure, as well as chronic constipation and hemorrhoids, were the clinical presentations related to USWs. This is the first report to show the clinical relevance of USWs to megacolon. USWs should be recognized as an important manometric finding indicating a possible new clinical entity in chronic constipation.

keywords —— ultra slow wave; manometry; constipation; megacolon; high anal pressure

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Tohoku J. Exp. Med., 2007, 211, 127-132

Correspondence: Hiroyuki Kayaba, M.D., Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Hondo 1-1-1, Akita 010-8543, Japan.

e-mail: kayaba@hos.akita-u.ac.jp
^*Yoshino, H. and Kayaba, H. equally contributed to this article.