Increased Serum Malondialdehyde Levels in Chronic Stage of Ischemic Stroke

Increased Serum Malondialdehyde Levels in Chronic Stage of Ischemic Stroke

LEVENT SINAN BIR, SÜLEYMAN DEMIR,¹ SIMIN ROTA¹ and MEHMET KÖSEOGLU²

Department of Neurology, ¹Department of Biochemistry, Pamukkale University Medical School, Denizli, Turkey, and ²Department of Biochemistry, Atatürk Education and Research Hospital, Izmir, Turkey

Serum lipoperoxidation products such as malondialdehyde (MDA) reflect oxidative stress. There are contradictory results addressing the levels of lipoperoxidation products in chronic phase of ischemic stroke. In the present study, we aimed to determine the serum MDA levels in stroke patients 6 months after the cerebrovascular accident. We also compared serum MDA levels in two major groups of patients with ischemic stroke resulting from small vessel and large vessel diseases, respectively. Serum MDA levels of thirty-eight patients who had ischemic stroke (19 with atherothrombotic ischemic stroke and 19 with lacunar infarction) and 30 healthy volunteers were measured. While there was no significant difference in serum MDA levels between the chronic ischemic stroke subgroups (p = 0.795), the serum MDA levels of patients with atherothrombotic ischemic stroke (p < 0.001) or with lacunar infarction (p < 0.001) were significantly higher compared to the control group. We also demonstrated that serum MDA levels of the patients with and those without hypertension (p = 0.846), diabetes mellitus (p = 0.891), or dyslipidemia (p = 0.38) were not significantly different. In conclusion, serum MDA levels were elevated in chronic stroke patients with small or large vessel diseases. To the best of our knowledge, this is the first report showing that serum MDA levels of these two groups are not sigificantly different. Furthermore, serum MDA levels do not differ solely by the existence or nonexistence of hypertension, diabetes mellitus or hyperlipidemia.

keywords —— ischemic stroke; chronic stroke; malondialdehyde; MDA; oxidative stress

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Tohoku J. Exp. Med., 2006, 208, 33-39

Received September 6, 2005; revision accepted for publication October 14, 2005.
Correspondence: Dr. Simin Rota, PK 259 Yenisehir, 06443 Ankara, Turkey.

e-mail: siminrota@yahoo.co.uk