Tohoku J. Exp. Med., 2005, 207(4)
The Protective Effects of Amifostine on Adriamycin-Induced Acute Cardiotoxicity in Rats
ZAHIT BOLAMAN, CEYHAN CICEK, GURHAN KADIKOYLU, SABRI BARUTCA,1 MUKADDER SERTER,2 CIGDEM YENISEY2 and GULINAZ ALPER3
Department of Internal Medicine, Division of Hematology, 1Division of Oncology, 2Deparment of Biochemistry, Adnan Menderes University Medical School, Aydin, Turkey, and 3Deparment of Biochemistry, Aegan University Medical School, Izmir, Turkey
Free oxygen radicals and lipid peroxidation are responsible for adriamycin-induced cardiotoxicity. Amifostine is a scavenger of free radicals and may function as a selective cytoprotective agent. The aim of this study was to investigate the effects of amifostine on adriamycin-induced lipid peroxidation and the levels of protective enzymes in the heart. Male Wistar rats were randomly allocated to three groups: pretreated, untreated, and control (
keywords —— adriamycin; amifostine; acute cardiotoxicity; malondialdehyde; catalase
© 2005 Tohoku University Medical Press
===============================
Tohoku J. Exp. Med., 2005, 207, 249-253
Correspondence: Dr. Zahit Bolaman, Adnan Menderes Universitesi, Tip Fakultesi, Ic Hastaliklari AD, Hematoloji BD, 09100 Aydin, Turkey.
e-mail: zahitb@yahoo.com