Decreased Serum Lipoprotein Levels as a Guide for Clinical Severity in Patients with Idiopathic Dilated Cardiomyopathy

Decreased Serum Lipoprotein Levels as a Guide for Clinical Severity in Patients with Idiopathic Dilated Cardiomyopathy

NURZEN SEZGIN, ALPAY T. SEZGIN,¹ HAKAN GULLU,¹ AYSUN KARABULUT, IRFAN BARUTCU,¹ ERGUN TOPAL,¹ DEFNE YALCINTAS² and ISMAIL TEMEL

Departments of Biochemistry, ¹Cardiology, Inonu University Medical Faculty, Malatya, and ²Department of Statistics, Baskent University, Adana Research and Practice Center, Adana, Turkey

Hyperlipidemia is a cardiovascular risk factor. In patients with idiopathic dilated cardiomyopathy (IDC), prognostic roles of endogenous lipoproteins are not fully clarified. It has been known that there is a direct relationship between the levels of cytokines (tumor necrosis factor-α [TNF-α] and interleukin-6 [IL-6]) and deteriorating functional classes of heart failure and mortality. The present study compared the levels of circulating TNF-α, IL-6, lipoproteins, and apolipoproteins in patients with stable IDC (n = 28) with those of patients with unstable IDC (n = 26) and controls (n = 24). Mean serum total cholesterol (TC) was significantly lower in stable IDC patients than controls (p < 0.05). In unstable IDC patients, mean serum TC was also lower than controls but not statistically significant. The IDC patients had significantly higher concentrations of IL-6 and TNF-α than the controls (p < 0.01). Serum IL-6 and Apo AI levels were significantly different between stable and unstable IDC patients (p = 0.021 and p = 0.012, respectively). Increased levels of IL-6 were associated with decreased levels of TC (r = −0.266, p = 0.019), LDL-C (r = −0.376, p = 0.001) and apolipoprotein AI (apo AI) (r = −0.495, p < 0.001) in all IDC patients. TNF-α was also inversely related to apo AI (r = −0.455, p < 0.001) and LDL-C (r = −0.364, p = 0.001) in all patients. Thus, elevated serum levels of cytokines in patients with IDC are associated with decreased lipoprotein concentrations, which may indicate impaired prognosis.

keywords —— heart failure; lipoprotein; apolipoprotein; cytokine

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Tohoku J. Exp. Med., 2005, 206, 219-224

Correspondence: Nurzen Sezgin, M.D., Baskent University Adana Research and Practice Center, Department of Biochemistry, Dadaloglu Mah. 39. Sok. No: 6, Yuregir, Adana, 01250 Turkey.

e-mail: nurzensezgin@hotmail.com