Cognitive Event-Related Potential and Neuropsychological Findings in Behçet's Disease without Neurological Manifestations
HANDAN ISIN OZISIK, RIFAT KARLIDAG,1 ERSOY HAZNECI,2 SIBEL KIZKIN and CEMAL OZCAN
Department of Neurology, 1Department of Psychiatry, and 2Department of Dermatology, Medical Faculty of Inönü University, Malatya, Turkey
Behçet's disease (BD) is a multisystem inflammatory disorder characterized by recurrent oral and genital ulcers and uveitis. BD patients without neurological involvement frequently have mild neurological symptoms. The aim of this study was to evaluate whether BD patients without neurological involvement have any changes in cognitive functions. Twenty BD patients without neurological involvement and 13 control subjects were included in the study and were analyzed by neurophysiological and neuropsychological examinations. The cognitive event-related potentials (P300) were recorded from the frontal, central and parietal areas of the right and left hemispheres of the patients and control subjects. Likewise, all individuals were evaluated with neuropsychological tests. In contrast to a study with similar design, we did not find any difference between the cognitive event-related potentials values of BD patients without neurological involvement and the control subjects. All BD patients without neurological involvement exhibit normal results of the neuropsychological test. In conclusion, the results of neuropsychological tests and cognitive event-related potentials values in BD patients without neurological involvement are indistinguishable from those in control subjects and no alteration of cognitive functions is present.
keywords —— cognitive event-related potentials; neuropsychological tests; Behçet's disease
© 2005 Tohoku University Medical Press
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Tohoku J. Exp. Med., 2005, 206, 15-22
Correspondence: Dr. Handan Isin Ozisik, Assistant Professor of Neurology, Inönü Üniversitesi Tip Fakültesi, Turgut Özal Tip Merkezi, Nöroloji Anabilim Dali, 44330, Malatya, Turkey.
e-mail: hozisik@inonu.edu.tr, handanisin@yahoo.com