Retrospective Analysis of Concurrent Chemoradiation with the Combination of Bleomycin, Ifosfamide and Cisplatin (BIP) for Uterine Cervical Cancer

Retrospective Analysis of Concurrent Chemoradiation with the Combination of Bleomycin, Ifosfamide and Cisplatin (BIP) for Uterine Cervical Cancer

MICHIKO AOKI, JUN-ICHI AKAHIRA, HITOSHI NIIKURA, SUMIKA SAITO, YORIKO ABE, TAKESHI AIDA, NAOKO SATO, TAKAKO KITAMURA, KENRO OTSUKI, ATSUKO KATAHIRA, HIROKI UTSUNOMIYA, CHIKAKO OKAMURA, TADAO TAKANO, KIYOSHI ITO, KUNIHIRO OKAMURA and NOBUO YAEGASHI

Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan

Combination chemotherapy consisting of bleomycin, ifosfamide, and ciplatin (BIP) is recognized as one of the most effective chemotherapies for uterine cervical cancer. However, there have been no reports that evaluate concurrent use of radiation with BIP. The objective of this study was to evaluate the toxicity and response of the combination of BIP concurrent with radiation in patients with squamous cell carcinoma of the uterine cervix. Eligibility criteria included patients who underwent radical hysterectomy (Type III hysterectomy) as a primary treatment and revealed lymph node metastases or deep myometrial invasion (stage IB and IIA) and patients who were previously untreated (stage IIB-IV). All of the patients had biopsy-proven squamous cell carcinoma of the uterine cervix. The patients received three courses of BIP chemoradiation, and the response and toxicity were evaluated. From January 2000 to December 2003, 30 patients met study eligibility criteria. All but three patients completed 3 courses of planned chemotherapy. The frequency of severe (grade 3 and 4) toxicity was as follows: anemia, 46.7%; neutrocytopenia, 73.3%; thrombocytopenia, 16.7%; and nausea and vomiting, 23.3%. Among 30 patients, 22 cases were evaluated for response. Complete response was achieved in 16 (72.7%) of patients, with a response rate of 90.9%. In conclusion, BIP chemoradiation seems to be superior to previously reported chemoradiation regimens, and has a potential as an optimal combination chemotherapy concurrent with radiation.

keywords —— clinical trial; chemoradiation; cervical carcinoma; BIP

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Tohoku J. Exp. Med., 2004, 204, 309-315

Address for reprints: Jun-ichi Akahira, M.D., Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

e-mail: jakahira-tohoku@umin.ac.jp