Tohoku J. Exp. Med., 2004, 202(1)

Case Report

Effect of Intra-Arterial Cisplatin on Multiple Liver Metastases from Rectal Cancer Associated withUlcerative Colitis

CHIKASHI SHIBATA, XUE-LIN JIN, YUJI FUNAYAMA, KOUHEI FUKUSHIMA, KEN-ICHI TAKAHASHI, AKIHIKO HASHIMOTO, MUNENORI NAGAO, SHO HANEDA, KAZUHIRO WATANABE, SEIKI MATSUNO, IWAO SASAKI and HIROO NAITO¹

Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8574, and1Department of Surgery, South Miyagi Medical Center, Ogawara 989-1305

We report a patient with synchronous multiple liver metastases from rectal cancer associated with ulcerative colitis. Because the liver tumors were unresectable, we performed total proctocolectomy and hepatic intra-arterial cisplatin infusion with systemic oral administration of fluorouracil. A complete response was obtained. The patient is alive without sign of recurrence 5 years postoperatively. Hepatic intra-arterial administration of cisplatin should be considered in the treatment of unresectable liver metastases from colorectal cancer.

keywords —— cisplatin; colitic cancer; liver metastasis; ulcerative colitis

© 2004 Tohoku University Medical Press

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Address for reprints: Chikashi Shibata, MD, Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

e-mail: cshibata@gonryo.med.tohoku.ac.jp