Influence of Acute Exercise on Urinary Protein, Creatinine, Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 Concentrations in Children

Influence of Acute Exercise on Urinary Protein, Creatinine, Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 Concentrations in Children

GÜNFER TURGUT, BÜNYAMIN KAPTANOGLU,¹ SEBAHAT TURGUT, OSMAN GENI and SEZGIN TEKINTÜRK¹

Physiology and ¹Biochemistry Departments of Medical Faculty, Pamukkale University, Denizli, Turkey

Insulin-like growth factor-I (IGF-I) is a polypeptide hormone and present in human urine. Insulin-like growth factor binding protein-3 (IGFBP-3) is the major form of binding protein in human circulation and functions as a carrier for IGF-I. Our goal was to determine the effects of volleyball exercise on the concentrations of urine protein, creatinine, IGF-I, and IGFBP-3 in children and to find out whether these effects differ between boys and girls. Volunteer children (13 females and 14 males), aged 10-13 years old were included in this work. Weight and height of the subjects were measured, and urine samples of their were collected before and after 2 hours of exercise. Urinary protein, creatinine, IGF-I and IGFBP-3 levels were analysed. Urinary protein, creatinine and IGF-I concentrations were increased after two hours of exercise wheres urinary IGFBP-3 concentrations did not change. In addition, no statistically significant difference in all parameters analysed was observed between boys and girls of similar age and body mass index.

keywords —— insulin-like growth factor-I (IGF-I); insulin-like growth factor binding protein-3 (IGFBP-3); protein; creatinine; exercise

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Tohoku J. Exp. Med., 2003, 201, 165-170

Address for reprints: Dr. Günfer Turgut, M.D., Ph.D. Pamukkale Üniversitesi Tip Fak. Fizyoloji A.D., P.K. 33, 20020 Denizli, Turkey.

e-mail: gturgut@pamukkale.edu.tr