Tohoku J. Exp. Med., 2003, 201 (2)

Short Report

Role of Adenosine in Regulation of Uterine Blood Flow
during Nonpreeclamptic Twin Gestation

SHUNJI SUZUKI and YOSHIO YONEYAMA¹

Department of Obstetrics and Gynecology, Tokyo Rinkai Hospital, Tokyo 134-0086, and
¹Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo 113-8603

We evaluated the possible role of increased adenosine in the regulation of uteroplacental circulation during nonpreeclamptic twin gestations. We performed uterine artery Doppler velocimetry and maternal arterial blood sampling for measurement of plasma adenosine levels in 16 women with singleton gestation and 14 women with dichorionic twin gestation without preeclampsia at 11-12, 25-26 and 34-36 weeks. In singleton gestations, a negative correlation between maternal plasma adenosine levels and maternal uterine artery pulsatility index was observed. In twin gestations, there were no noticeable association between maternal plasma adenosine levels and maternal uterine artery pulsatility index. Our results suggest that the decrease in vascular resistance in twin gestations may be through the mechanisms that are independent of adenosine.

keywords —— twin gestation; uterine artery; pulsatility index; plasma adenosine

© 2003 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2003, 201, 127-130

Address for reprints: Shunji Suzuki, M.D., Department of Obstetrics and Gynecology, Tokyo Rinkai Hospital, 1-4-2 Rinkai-cho, Edogawa-ku, Tokyo 134-0086, Japan.

e-mail: czg83542@mopera.ne.jp