Tohoku J. Exp. Med., 2003, 201 (1)

Case Report

Elevated Concentrations of Soluble IL-2 Receptor
in both Bronchoalveolar Lavage Fluid
and Serum in a Patient with BOOP

OSAMU MATSUNO, FUMIKO OKUBO, KAZUHIRO MASUTOMO, FUMIO YOSHIDA,
TOSIYUKI OKUBO,¹ EISHI MIYAZAKI¹ and TOSIHIDE KUMAMOTO¹

Department of Internal Medicine, Usuki Cosmos Hospital, Usuki, Oita 875-0051
¹Department of immunology and allergy, Oita Medical University, Hasama, Oita 879-5593

Activated soluble IL-2 receptor (sIL-2R) levels are elevated in a variety of diseases associated with T-cell activation. There are no reports of sIL-2R elevations in broncholitis obliterans organizing pneumonia/cryptogenic organizing pneumonia (BOOP/COP), although activated T cells are increased in BOOP/COP. We present a patient with BOOP/COP with an elevated concentration of soluble IL-2 receptors in both serum and bronchoalveolar lavage fluid. Concomitant resolution of the high serum sIL-2R and the roentogenographic findings after steroid treatment suggested that serum sIL-2R levels increase in response to a localized lymphocytic inflammatory reaction in the lung.

keywords —— BOOP/COP; soluble Il-2 receptor

© 2003 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2003, 201, 61-65

Address for reprints: Dr. Osamu Matsuno, M.D, Department of immunology and allergy, Oita Medical University, Hasama city, Oita 879-5593, Japan.

e-mail: matsuno@oita-med.ac.jp